I haven't had any real problems like this on XP or VISTA. I transferred a few modules from my main PC to my laptop and they opened OK.
I have ocassionally had incidents where I get errors related to parts of the module failing, usually not too difficult to fix though.
I do tend to keep all the recources relevant to the Courselab modules in discrete folders so I've always got all of the graphcs and text components collated in case it does all go wrong. They're also backed up onto my SAN.
Bad experiences in the past tend to make me a little on the paranoid side about keeping backups and spare copies.